Madonna and Child with Angels by http://www.wikidata.org/.well-known/genid/7da7fe6ad8a49e5b19312157ec0eaf22
This is the "Madonna and Child with Angels," painted around 1500. It's a devotional image common in Renaissance art. Notice the intimate gestures between mother and child, and the tender way the angels attend them.
Look at the central figures: Mary's hands are in prayer, her gaze directed down toward the infant. Jesus reaches up, a gesture that theologians interpret as Christ's ascent toward humanity via Mary.
The artist hid a tiny monogram on the edge of the circular frame. This signature was a way of asserting their presence and skill within the religious artwork.
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The Madonna holds her child gently. Her hands are pressed together in prayer. The infant Jesus reaches up to her face. This gesture symbolizes Christ reaching humanity. One angel touches Mary's sleeve with care. The artist signed this with a tiny monogram. It is hidden in the tondo's outer edge. The monogram is the artist's hidden signature.