The room's most celebrated works include Piero della Francesca's double portrait of the Duke and Duchess of Urbino, Federico da Montefeltro and Battista Sforza, painted around 1472. This diptych presents the couple in strict profile, following ancient coin conventions, with striking chromatic contrast between Federico's bronze skin tones and Battista's pale complexion, possibly alluding to her recent death. The reverse sides depict the couple triumphantly borne on ancient wagons accompanied by Christian virtues, with Latin inscriptions praising their moral qualities. Piero combined strict Florentine perspective with lenticular representation derived from Flemish painting. Fra Filippo Lippi's Coronation of the Virgin, completed in 1447 for the high altar of the Benedictine church of Sant'Ambrogio in Florence, also hangs here. Commissioned for more than 400 gold florins by canon Francesco di Antonio Maringhi, the altarpiece features complex spatial orchestration around a stone throne, with St. Ambrose and John the Baptist flanking the scene and a family of martyrs in the foreground. Lippi included his own portrait as a kneeling Carmelite friar in the background. The painting was moved to the sacristy after its original placement, stolen after 1755, passed through the collection of Angelo Volpini, entered the Galleria dell'Accademia in 1813, and has been at the Uffizi since 1913.