Madonna and Child with Saints

Lorenzo Lotto executed this oil-on-canvas painting in 1534, a date confirmed by the artist's signature on the work. Scholars suggest the composition may derive from an earlier prototype held in the Seilern Collection in London, which features a landscape visible through an open window rather than the figure of Saint Jerome found in this version.

The painting's documented history begins in the early eighteenth century, when it was recorded in the collections of the Palazzo Pitti in Florence. It currently resides in the Uffizi Gallery, having been transferred from the Pitti Palace.

The painting is currently held at the Uffizi Gallery in Florence. It was first documented at the Palazzo Pitti at the beginning of the 18th century before entering the Uffizi's collection. No specific inventory or accession number is recorded in the available sources, nor is any exhibition history noted.

Lorenzo Lotto's 1534 *Madonna and Child with Saints*, held in the Uffizi Gallery, represents a mature example of the *sacra conversazione* genre within the artist's later career. Scholarship identifies the work as a signed and dated oil-on-canvas painting that likely derives from a prototype in the Seilern Collection, distinguished by the substitution of Saint Jerome for an open landscape window. Art historical analysis highlights the composition's dynamic diagonals and the expressive intensity of the figures, particularly the ecstatic face of Saint Joseph. The painting is noted for its vivid color contrasts, restless drapery, and dramatic lighting that isolates the right-hand group while casting Saint Jerome in shadow. Documented at the Palazzo Pitti since the early 18th century, the work exemplifies Lotto's stylistic traits of emotional pathos and complex spatial arrangement characteristic of his mid-1530s output.